Advanced Data Management Platform for Biomarker Discovery and Research
Industry
Duration
Team
Technologies
Client Overview
Centogene is a biotechnology company specializing in genetic diagnostics for rare diseases, biomarker discovery, and clinical trial support. They provide advanced genetic testing services, identify and validate biomarkers, and assist in recruiting patients with specific rare genetic conditions for clinical trials. The platform helps researchers to manage mass spectrometry-based metabolomics experiments. The system organizes experimental data hierarchically, supports quality control measures, and incorporates advanced data processing techniques, including drift correction, peak mapping, and statistical analysis, tailored for biomarker discovery.
Client Needs
Clear Data Visualization
Quality Control Integration
Custom Machine Learning Algorithms
Statistical Analysis Tools
Centogene required a robust system to visualize, manage and analyze mass spectrometry-based metabolomics data. The platform needed to handle complex experimental data structures, support quality control processes, and facilitate advanced data processing techniques tailored for biomarker discovery.
Services Provided
Data Processing Pipeline: Implemented algorithms for drift correction, peak mapping, and data normalization.
Quality Control Integration: Enabled tracking and management of QC samples and flagged data anomalies.
Custom Machine Learning Algorithms: Developed specialized ML algorithms for clustering and feature selection in metabolomics data.
Statistical Analysis Tools: Integrated tools for calculating RSD, detection rates, and other key metrics.
Scope of Work
Designed a hierarchical data model to represent experimental structures including batches, measurements, and samples.
Implemented quality control mechanisms to track and manage QC samples and data anomalies.
Developed advanced data processing algorithms for drift correction, peak mapping, and normalization.
Developed custom machine learning algorithms for clustering and feature selection tailored to metabolomics data.
Implemented statistical analysis tools to calculate key metrics such as RSD and detection rates.
Technologies Used
React: Used for building the frontend user interface, providing an easy to navigate and interact experience for researchers.
Python: Utilized for developing data processing algorithms and system backend.
PostgreSQL: Used for storing and managing structured experimental data.
Docker: Containerized applications for consistent deployment across environments.
Redis: Utilized as a message broker for handling background tasks and caching.
Development Process
The project commenced with an in-depth analysis of Centogene's requirements for managing mass spectrometry data. We designed a hierarchical data model to represent batches, measurements, and samples. The development focused on integrating quality control processes, implementing advanced data processing algorithms, and ensuring secure user access through API tokens. Custom machine learning algorithms were developed to enhance biomarker discovery capabilities.
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